The evolution of phase I trials in cancer medicine: a critical review of the last decade / 癌症
Chinese Journal of Cancer
;
(12): 815-820, 2011.
Article
Dans Anglais
| WPRIM
| ID: wpr-294457
ABSTRACT
The advent of targeted therapies, combined with an unsustainable rate of failure in oncology drug development, has resulted in a number of new approaches to clinical trials. Early clinical trials are no exception, with efforts to improve the eventual success rate of late stage trials through evolving phase I trial methodologies, the addition of extensive pharmacodynamic studies, and early adoption of patient selection strategies. Unfortunately, some of these new approaches have met with mixed results. Furthermore, no clear metrics are available to determine whether these designs are more successful than previous strategies. This review examines the evolution of phase I trials and draws upon several examples of strategies that have been successful as well as those that have not, and outlines a pragmatic approach to phase I trials as our understanding of the molecular biology of individual malignancies emerges.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phtalazines
/
Pyridines
/
Quinazolines
/
Imagerie diagnostique
/
Pharmacocinétique
/
Systèmes de délivrance de médicaments
/
Essais cliniques de phase I comme sujet
/
Dose maximale tolérée
/
Utilisations thérapeutiques
/
Inhibiteurs de protéines kinases
Type d'étude:
Etude diagnostique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Chinese Journal of Cancer
Année:
2011
Type:
Article
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