Platelet-derived growth factor signaling in human malignancies / 癌症
Chinese Journal of Cancer
;
(12): 581-584, 2011.
Article
Dans Anglais
| WPRIM
| ID: wpr-294487
ABSTRACT
Platelet-derived growth factors (PDGFs) and their receptors were identified and purified decades ago. PDGFs are important during normal development and in human cancers. In particular, autocrine PDGF signaling has been implicated in various types of malignancies such as gliomas and leukemia. In contrast, paracrine signaling was found in cancers that originate from epithelial cells, where it may be involved in stromal cell recruitment, metastasis, and epithelial-mesenchymal transition. This editorial briefly discusses autocrine and paracrine PDGF signaling and their roles in human cancers, and introduces a series of review articles in this issue that address the possible roles of PDGFs in various processes involved in different types of cancers.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Physiologie
/
Facteur de croissance dérivé des plaquettes
/
Récepteurs aux facteurs de croissance dérivés des plaquettes
/
Communication autocrine
/
Communication paracrine
/
Transition épithélio-mésenchymateuse
/
Génétique
/
Métabolisme
/
Invasion tumorale
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Chinese Journal of Cancer
Année:
2011
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS