A IL-6R antagonist 2520A produced by a fungal species / 药学学报
Acta Pharmaceutica Sinica
;
(12): 662-665, 2006.
Article
Dans Chinois
| WPRIM
| ID: wpr-294963
ABSTRACT
<p><b>AIM</b>To isolate IL-6R antagonists from the cultured broth of the strain Torulomyces ovatus.</p><p><b>METHODS</b>Various column chromatographyes were used to separate and purify the compounds with IL-6R antagonist activity. The spectral data and physic-chemical properties were measured for structure identification.</p><p><b>RESULTS</b>One compound namely 2520 was isolated from the cultured broth of Torulomyces ovatus.</p><p><b>CONCLUSION</b>2520A is a known compound (ferrichrome). It is first reported about its antagonistic activity of IL-6R and identification of iron atom in its structure.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Peptides cycliques
/
Pharmacologie
/
Bacillus subtilis
/
Composés du fer III
/
Structure moléculaire
/
Survie cellulaire
/
Chimie
/
Récepteurs à l'interleukine-6
/
Lignée cellulaire tumorale
/
Deuteromycota
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2006
Type:
Article
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