Significance of chemokine receptor CXCR3 expression in breast cancer / 中华病理学杂志
Chinese Journal of Pathology
; (12): 85-88, 2011.
Article
de Zh
| WPRIM
| ID: wpr-295104
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of CXCR3 and its association with clinicopathologic features in breast carcinoma.</p><p><b>METHODS</b>The expression level of CXCR3 in 18 samples of breast cancer and corresponding normal tissues was investigated using reverse transcriptase-polymerase chain reaction (RT-PCR) and real-time RT-PCR analysis. Immunohistochemistry was carried out to examine the expression of CXCR3 in 80 breast cancers, 20 fibroadenomas and 15 normal breast tissues.</p><p><b>RESULTS</b>(1) RT-PCR and real-time RT-PCR analysis showed a higher level of CXCR3 in breast cancer tissues than that in the corresponding normal breast tissues (P < 0.05). (2) Immunohistochemistry analysis showed that the positive rate of CXCR3 in breast cancer tissues was significantly higher than that in fibroadenomas and the normal breast tissues (P < 0.05). The expression level of CXCR3 in the lymph node-positive group was higher than that in the lymph node-negative group (P < 0.05). The expression of CXCR3 was positively correlated with the number of lymph nodes involved by metastasis, tumor size and pTNM tumor stage (P < 0.05).</p><p><b>CONCLUSIONS</b>Chemokine receptor CXCR3 was up-regulated in breast cancer, and was associated with the progression of breast cancer. CXCR3 might be a novel molecular marker to predict lymph node metastasis and prognosis of breast cancer.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
/
Pronostic
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Tumeurs du sein
/
ARN messager
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Marqueurs biologiques tumoraux
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Fibroadénome
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Carcinome canalaire du sein
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Charge tumorale
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Récepteurs CXCR3
/
Génétique
Type d'étude:
Prognostic_studies
Limites du sujet:
Adult
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Aged
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Female
/
Humans
langue:
Zh
Texte intégral:
Chinese Journal of Pathology
Année:
2011
Type:
Article