Evaluation of two-tier grading system and significance of p53 protein over-expression in ovarian serous carcinoma / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 655-660, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-295159
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the two-tier MDACC grading system for ovarian serous carcinoma by comparing with the WHO grading system, and to investigate the role of p53 immunostaining in ovarian serous carcinoma grading.</p><p><b>METHODS</b>72 cases ovarian serous carcinoma of ovary were graded basing on the MDACC and WHO grading systems, respectively. Statistic analyses were made for the relationship between the data obtained from two grading systems and their clinical significance. All the cases were examined immunohistochemically by using antibody against p53 protein and the immunohistochemistry findings were analyzed with the two grading systems and clinical parameters.</p><p><b>RESULTS</b>There was a good correlation between the MDACC and WHO grading system (r=0.543, P=0.000). Neither system has a definite relationship with the disease-free survival time (P=0.170 vs. P=0.075), cytoreduction (P=0.478 vs. P=0.120), and the curative effect of platinum-based chemotherapy (P=0.418 vs. P=0.403). However, compared with the WHO grading system, MDACC grading system has a better correlation with tumor stage (P=0.041 vs. P=0.002), 3-year disease-free survival rate (P=0.077 vs. P=0.004), overall survival time (P=0.080 vs. P=0.046), and p53 immunohistochemistry results (P=0.334 vs. P=0.035). No significant difference was found between p53 immunohistochemistry results with other clinical characteristics and prognostic factors.</p><p><b>CONCLUSIONS</b>Compared with the WHO system, the MDACC system showed a better prognostic value and was more likely correlated with the novel dualistic model for ovarian serous carcinogenesis. Although p53 immunostaining was valuable in assisting MDACC grading, it should be cautious to use it alone as an independent indicator in predicting the prognosis of ovarian serous carcinoma.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tumeurs de l'ovaire
/
Anatomopathologie
/
Chirurgie générale
/
Organisation mondiale de la santé
/
Protocoles de polychimiothérapie antinéoplasique
/
Taux de survie
/
Études de suivi
/
Protéine p53 suppresseur de tumeur
/
Composés du platine
/
Cystadénocarcinome séreux
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Adulte
/
Adulte très âgé
/
Aged80
/
Femelle
/
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Pathology
Année:
2010
Type:
Article
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