Expressions of Ep-CAM and cyclin D1 and their clinical significance in gallbladder carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 841-844, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-295223
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expressions of Ep-CAM and cyclin D1 and their correlation with the clinicopathological factors and prognosis in gallbladder carcinoma.</p><p><b>METHODS</b>Ep-CAM and cyclin D1 expressions were detected by PV6000 immunohistochemical staining in 60 gallbladder carcinoma and 15 para-cancerous mucosa specimens.</p><p><b>RESULTS</b>Ep-CAM and cyclin D1 expressions were detected in 56.7% and 48.3% of the cancer tissues, respectively, significantly higher than those in the normal mucosa (P < 0.05). Ep-CAM expression was not correlated with clinicopathological data, however cyclin D1 expression was correlated with pathological differentiation and necrosis (P < 0.05). Survival analysis showed that patients with positive Ep-CAM or cyclin D1 expression had a shorter survival time than that in the patients without (P < 0.05). Moreover, Ep-CAM and cyclin D1 expressions were positively correlated with each other (r = 0.307, P = 0.017).</p><p><b>CONCLUSION</b>Ep-CAM or cyclin D1 expression is a unfavorable prognostic factor in gallbladder carcinoma.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Carcinome épidermoïde
/
Adénocarcinome
/
Molécules d'adhérence cellulaire
/
Différenciation cellulaire
/
Taux de survie
/
Carcinome adénosquameux
/
Cycline D1
/
Molécule d'adhérence des cellules épithéliales
/
Tumeurs de la vésicule biliaire
Type d'étude:
Étude pronostique
Limites du sujet:
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Oncology
Année:
2009
Type:
Article
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