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Estimation on gene-environment interaction in the partial case-control study / 中华流行病学杂志
Chinese Journal of Epidemiology ; (12): 72-75, 2006.
Article Dans Chinois | WPRIM | ID: wpr-295600
ABSTRACT
<p><b>OBJECTIVE</b>To introduce the approaches for estimating gene-environment interaction based on partial case-control studies.</p><p><b>METHODS</b>The effects of logistic model and log-linear model for estimating the main effects and gene-environment interaction effect were estimated by means of maximum likelihood methods in traditional case-control studies, case-only studies and partial case-control studies, respectively. An example was also illustrated.</p><p><b>RESULTS</b>In traditional case-control study with complete data, the results of logistic model and log-linear model were equivalent. In case-only study without any information about controls, the logistic model can also efficiently estimate gene-environment interaction. In partial case-control study, environmental information was collected from all of the cases and controls, while genetic information was only collected from cases. For this case-control study with incomplete data, a suitable parameterized log-linear model could simultaneously and efficiently estimate the main effect of environment and gene-environment interaction, whereas the logistic model could not.</p><p><b>CONCLUSION</b>For a partial case-control study, log-linear model could estimate not only the main effect of environment but also gene-environment interaction. If genotype and exposure were independent, estimators from partial case-control were as precisely as those from complete-data case-control studies.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Études cas-témoins / Modèles linéaires / Modèles logistiques / Reproductibilité des résultats / Modèles statistiques / Environnement / Génotype Type d'étude: Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Humains langue: Chinois Texte intégral: Chinese Journal of Epidemiology Année: 2006 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Études cas-témoins / Modèles linéaires / Modèles logistiques / Reproductibilité des résultats / Modèles statistiques / Environnement / Génotype Type d'étude: Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Humains langue: Chinois Texte intégral: Chinese Journal of Epidemiology Année: 2006 Type: Article