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Second-generation tyrosine kinase inhibitors combined with allogeneic hematopoietic stem cell transplant for Philadelphia chromosome positive leukemia / 中华血液学杂志
Chinese Journal of Hematology ; (12): 129-133, 2014.
Article de Zh | WPRIM | ID: wpr-295694
Bibliothèque responsable: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the efficacy and safety of second-generation tyrosine kinase inhibitors (TK-II) combined with allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the treatment of high-risk Philadelphia chromosome positive (Ph⁺) leukemia.</p><p><b>METHODS</b>The clinical data of 17 cases of high-risk Ph⁺ leukemia patients underwent allo-HSCT were retrospectively analyzed, including 1 case in accelerated phase and 7 cases in blast crises of chronic myeloid leukemia, and 9 cases of Ph⁺ acute lymphoblastic leukemia. Nilotinib or Dasatinib were administered before and (or) after allo-HSCT in all patients.</p><p><b>RESULTS</b>All patients successfully engrafted. Median times to neutrophil and platelet recovery were 12 days (range 10-14) and 15 days (range 11- 23), respectively. Acute GVHD developed in 7 patients: 6 patients had grade 1 to 2 and 1 patient grade 3. Chronic GVHD developed in 6 patients, all were limited and no lethal GVHD occurred. At a median follow-up of 17(range 3-60) months, 11(64.7%) patients survived disease free, 6 patients relapsed and 5 died.</p><p><b>CONCLUSION</b>TK-II combined with allo-HSCT effectively improved the remission rate of high-risk Ph⁺ leukemia and reduced recurrence after allo-HSCT, which represented an important improvement in the treatment of patients with high-risk Ph+ leukemia.</p>
Sujet(s)
Texte intégral: 1 Indice: WPRIM Sujet Principal: Thérapeutique / Transplantation homologue / Protein-tyrosine kinases / Chromosome Philadelphie / Leucémie myéloïde chronique BCR-ABL positive / Études rétrospectives / Transplantation de cellules souches hématopoïétiques / Utilisations thérapeutiques / Inhibiteurs de protéines kinases / Leucémie-lymphome lymphoblastique à précurseurs B et T Type d'étude: Observational_studies Limites du sujet: Adolescent / Adult / Female / Humans / Male langue: Zh Texte intégral: Chinese Journal of Hematology Année: 2014 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Thérapeutique / Transplantation homologue / Protein-tyrosine kinases / Chromosome Philadelphie / Leucémie myéloïde chronique BCR-ABL positive / Études rétrospectives / Transplantation de cellules souches hématopoïétiques / Utilisations thérapeutiques / Inhibiteurs de protéines kinases / Leucémie-lymphome lymphoblastique à précurseurs B et T Type d'étude: Observational_studies Limites du sujet: Adolescent / Adult / Female / Humans / Male langue: Zh Texte intégral: Chinese Journal of Hematology Année: 2014 Type: Article