Second-generation tyrosine kinase inhibitors combined with allogeneic hematopoietic stem cell transplant for Philadelphia chromosome positive leukemia / 中华血液学杂志
Chinese Journal of Hematology
; (12): 129-133, 2014.
Article
de Zh
| WPRIM
| ID: wpr-295694
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the efficacy and safety of second-generation tyrosine kinase inhibitors (TK-II) combined with allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the treatment of high-risk Philadelphia chromosome positive (Ph⁺) leukemia.</p><p><b>METHODS</b>The clinical data of 17 cases of high-risk Ph⁺ leukemia patients underwent allo-HSCT were retrospectively analyzed, including 1 case in accelerated phase and 7 cases in blast crises of chronic myeloid leukemia, and 9 cases of Ph⁺ acute lymphoblastic leukemia. Nilotinib or Dasatinib were administered before and (or) after allo-HSCT in all patients.</p><p><b>RESULTS</b>All patients successfully engrafted. Median times to neutrophil and platelet recovery were 12 days (range 10-14) and 15 days (range 11- 23), respectively. Acute GVHD developed in 7 patients: 6 patients had grade 1 to 2 and 1 patient grade 3. Chronic GVHD developed in 6 patients, all were limited and no lethal GVHD occurred. At a median follow-up of 17(range 3-60) months, 11(64.7%) patients survived disease free, 6 patients relapsed and 5 died.</p><p><b>CONCLUSION</b>TK-II combined with allo-HSCT effectively improved the remission rate of high-risk Ph⁺ leukemia and reduced recurrence after allo-HSCT, which represented an important improvement in the treatment of patients with high-risk Ph+ leukemia.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Thérapeutique
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Transplantation homologue
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Protein-tyrosine kinases
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Chromosome Philadelphie
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Leucémie myéloïde chronique BCR-ABL positive
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Études rétrospectives
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Transplantation de cellules souches hématopoïétiques
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Utilisations thérapeutiques
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Inhibiteurs de protéines kinases
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Leucémie-lymphome lymphoblastique à précurseurs B et T
Type d'étude:
Observational_studies
Limites du sujet:
Adolescent
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Adult
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Hematology
Année:
2014
Type:
Article