The absence of the ERBB4 hotspot mutations in melanomas in patients from southern China / 癌症
Chinese Journal of Cancer
;
(12): 410-414, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-295819
ABSTRACT
V-erb-a erythroblastic leukemia viral oncogene homolog 4 (ERBB4) has been reported to be somatically mutated in 19% of melanoma cases. To investigate the prevalence of ERBB4 mutations in melanoma patients from southern China, we analyzed 117 formalin-fixed, paraffin-embedded melanoma samples archived in the Sun Yat-sen University Cancer Center. A matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) platform was used to screen for mutations. No ERBB4 hotspot mutations were detected. Our results indicate that ERBB4 mutations may play a limited role in melanomas in China; therefore, targeting the ERBB4 mutation in melanoma patients from southern China may not be a promising strategy.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tumeurs cutanées
/
ADN tumoral
/
Inclusion en paraffine
/
Spectrométrie de masse MALDI
/
Asiatiques
/
Membres
/
Récepteurs ErbB
/
Récepteur ErbB-4
/
Génétique
/
Mélanome
Limites du sujet:
Adulte
/
Adulte très âgé
/
Aged80
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Chinese Journal of Cancer
Année:
2013
Type:
Article
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