Role of autophagy in acute myeloid leukemia therapy / 癌症
Chinese Journal of Cancer
;
(12): 130-135, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-295849
ABSTRACT
Despite its dual role in determining cell fate in a wide array of solid cancer cell lines, autophagy has been robustly shown to suppress or kill acute myeloid leukemia cells via degradation of the oncogenic fusion protein that drives leukemogenesis. However, autophagy also induces the demise of acute leukemia cells that do not express the known fusion protein, though the molecular mechanism remains elusive. Nevertheless, since it can induce cooperation with apoptosis and differentiation in response to autophagic signals, autophagy can be manipulated for a better therapy on acute myeloid leukemia.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Autophagie
/
Trétinoïne
/
Leucémie aigüe myéloïde
/
Leucémie aiguë promyélocytaire
/
Protéines de fusion oncogènes
/
Apoptose
/
Utilisations thérapeutiques
/
Traitement médicamenteux
/
Protéines régulatrices de l'apoptose
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Chinese Journal of Cancer
Année:
2013
Type:
Article
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