Individualized leukemia cell-population profiles in common B-cell acute lymphoblastic leukemia patients / 癌症
Chinese Journal of Cancer
;
(12): 213-223, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-295857
ABSTRACT
Immunophenotype is critical for diagnosing common B-cell acute lymphoblastic leukemia (common ALL) and detecting minimal residual disease. We developed a protocol to explore the immunophenotypic profiles of common ALL based on the expression levels of the antigens associated with B lymphoid development, including IL-7Rα (CD127), cytoplasmic CD79a (cCD79a), CD19, VpreB (CD179a), and sIgM, which are successive and essential for progression of B cells along their developmental pathway. Analysis of the immunophenotypes of 48 common ALL cases showed that the immunophenotypic patterns were highly heterogeneous, with the leukemic cell population differing from case to case. Through the comprehensive analysis of immunophenotypic patterns, the profiles of patient-specific composite leukemia cell populations could provide detailed information helpful for the diagnosis, therapeutic monitoring, and individualized therapies for common ALL.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Lymphocytes B
/
Immunophénotypage
/
Antigènes CD19
/
Récepteurs à l'interleukine-7
/
Allergie et immunologie
/
Antigènes CD79
/
Leucémie-lymphome lymphoblastique à précurseurs B et T
/
Pseudochaines légères des immunoglobulines
/
Métabolisme
Type d'étude:
Guide de pratique
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Chinese Journal of Cancer
Année:
2013
Type:
Article
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