Epigenetic disruption of cell signaling in nasopharyngeal carcinoma / 癌症
Chinese Journal of Cancer
;
(12): 231-239, 2011.
Article
Dans Anglais
| WPRIM
| ID: wpr-296291
ABSTRACT
Nasopharyngeal carcinoma (NPC) is a malignancy with remarkable ethnic and geographic distribution in southern China and Southeast Asia. Alternative to genetic changes, aberrant epigenetic events disrupt multiple genes involved in cell signaling pathways through DNA methylation of promoter CpG islands and/or histone modifications. These epigenetic alterations grant cell growth advantage and contribute to the initiation and progression of NPC. In this review, we summarize the epigenetic deregulation of cell signaling in NPC tumorigenesis and highlight the importance of identifying epigenetic cell signaling regulators in NPC research. Developing pharmacologic strategies to reverse the epigenetic-silencing of cell signaling regulators might thus be useful to NPC prevention and therapy.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Protéines de répression
/
Altération de l'ADN
/
Carcinomes
/
Transduction du signal
/
Cycle cellulaire
/
Tumeurs du rhinopharynx
/
Protéine p53 suppresseur de tumeur
/
Apoptose
/
Protéines G ras
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Chinese Journal of Cancer
Année:
2011
Type:
Article
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