GWAS signals across the HLA regions: revealing a clue for common etiology underlying infectious tumors and other immunity diseases / 癌症
Chinese Journal of Cancer
;
(12): 226-230, 2011.
Article
Dans Anglais
| WPRIM
| ID: wpr-296292
ABSTRACT
Increasing evidence suggests that multiple genes in the human leukocyte antigen(HLA) regions play an important role in development of cancers and immunity disorders. However, the biological mechanisms of the HLA associations are not well understood. We recently conducted a survey of all genome-wide association studies (GWAS) with significant findings in the HLA regions and concluded that diseases such as cancer and immune disorders are more likely to be associated with genetic variants located in the HLA regions than other diseases. This finding is suggestive for testing a hypothesis of a common etiology of infectious tumors and other immunity diseases.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Variation génétique
/
Virologie
/
Lymphome malin non hodgkinien
/
Tumeurs du rhinopharynx
/
Herpèsvirus humain de type 4
/
Prédisposition génétique à une maladie
/
Allergie et immunologie
/
Étude d'association pangénomique
/
Génétique
/
Antigènes HLA
Type d'étude:
Etude d'étiologie
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Chinese Journal of Cancer
Année:
2011
Type:
Article
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