Genetic Variants in the ELOVL5 but not ELOVL2 Gene Associated with Polyunsaturated Fatty Acids in Han Chinese Breast Milk / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 64-67, 2017.
Article
Dans Anglais
| WPRIM
| ID: wpr-296515
ABSTRACT
The present study was designed to examine the contributions of the fatty acid elongase (ELOVL) gene polymorphisms to the levels of polyunsaturated fatty acids (PUFAs) in breast milk. Two hundred and nine healthy Han Chinese mothers were included in the study. Carriers of minor alleles of SNPs (rs2397142 and rs9357760) in ELOVL5 were associated with higher levels of linoleic acid (LA), dihomo-γ-linolenic acid (DGLA), arachidonic acid (AA), docosatetraenoic acid (DTA), docosahexenoic acid (DHA), while in rs209512 of ELOVL5 the carriers of minor alleles had lower levels of DTA compared to major homozygote alleles (P ranged from 0.004-0.046), and genetically explained variability ranged from 3.2% for eicosapentaenoic acid (EPA) to 6.0% for LA. Our findings demonstrated that common variation in ELOVL5 gene encoding rate-limiting enzymes in the metabolism of PUFAs contribute to the PUFAs in breast milk.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Acetyltransferases
/
Chimie
/
Chine
/
Polymorphisme de nucléotide simple
/
Asiatiques
/
Acides gras insaturés
/
Génétique
/
Lait humain
Limites du sujet:
Femelle
/
Humains
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Biomedical and Environmental Sciences
Année:
2017
Type:
Article
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