Estrogen on stimulating the angiogenesis of children's hemangioma in vitro / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 86-90, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-297092
ABSTRACT
<p><b>OBJECTIVE</b>To demonstrate that estrogen stimulates the angiogenesis of children' s hemangioma.</p><p><b>METHODS</b>A piece of hemangioma biopsy was embedded in fibrin gel, and a model in vitro of angiogenesis of human hemangioma was then established. The angiogenesis of hemangioma in each group was interfered by the estrogen and tamoxifen. There were four groups divided into the followings the group with estrogen, the group with tamoxifen, the group with estrogen + tamoxifen and the control. The dimension of newborn tubule area in the 3rd, 6th, 9th day after the culture was calculated to compare statistically differences among the groups.</p><p><b>RESULTS</b>In the model of angiogenesis of hemangioma, microvessels grew out from the tissue sample in 2 to 3 days after the culture, and in 8 to 9 days a complex network of microvessels had been shown, the tending to inactivity. On the 3rd,6th and 9th day after the culture the dimension of newborn tubule area of the group of estrogen [(2.84 +/- 0.20) mm2 (12.93 +/- 0.85) mm2 (22.47 +/- 1.40) mm2] were larger than those of the control [(1.98 +/- 0.17) mm2, (7.51 +/- 0.48) mm2, (11.26 +/- 0.73) mm2]. Those of the group of estrogen + tamoxifen [(1.08 +/- 0.11) mm2, (3.54 +/- 0.31) mm2, (5.72 +/- 0.40 mm2] and the group of tamoxifen [(1.13 +/- 0.14) mm2 (4.26 +/- 0.29) mm2, (6.08 +/- 0.42) mm2] were smaller than those of the groups of the estrogen and the control (P < 0.05).</p><p><b>CONCLUSIONS</b>The estrogen may stimulate the angiogenesis of children's hemangioma, and the tamoxifen may reverse the process.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Techniques in vitro
/
Oestrogènes
/
Hémangiome
/
Néovascularisation pathologique
Limites du sujet:
Enfant
/
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Plastic Surgery
Année:
2007
Type:
Article
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