Advances in genetic research of cerebral palsy / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 1022-1026, 2017.
Article
de Zh
| WPRIM
| ID: wpr-297162
Bibliothèque responsable:
WPRO
ABSTRACT
Cerebral palsy is a group of syndromes caused by non-progressive brain injury in the fetus or infant and can cause disabilities in childhood. Etiology of cerebral palsy has always been a hot topic for clinical scientists. More and more studies have shown that genetic factors are closely associated with the development of cerebral palsy. With the development and application of various molecular and biological techniques such as chromosome microarray analysis, genome-wide association study, and whole exome sequencing, new achievements have been made in the genetic research of cerebral palsy. Chromosome abnormalities, copy number variations, susceptibility genes, and single gene mutation associated with the development of cerebral palsy have been identified, which provides new opportunities for the research on the pathogenesis of cerebral palsy. This article reviews the advances in the genetic research on cerebral palsy in recent years.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Paralysie cérébrale
/
Cytokines
/
Aberrations des chromosomes
/
Prédisposition génétique à une maladie
/
Étude d'association pangénomique
/
Variations de nombre de copies de segment d'ADN
/
Génétique
/
Mutation
Type d'étude:
Prognostic_studies
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Chinese Journal of Contemporary Pediatrics
Année:
2017
Type:
Article