HCN ion channel: biological characteristics and functions in pain / 生理学报
Acta Physiologica Sinica
;
(6): 423-430, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-297475
ABSTRACT
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in vertebrate are reverse voltage-dependent, and its activation depends on the hyperpolarization of cell and may be directly or indirectly regulated by the cyclic adenosine monophosphate (cAMP) or other signal transduction cascades. The distribution, quantity, and activation states of HCN channels differ in tissues throughout the body. By modulating If/If current, HCN channels may influence the resting membrane potential, and thus importantly regulate neuronal excitability, dendritic integration of synaptic potentials, and synaptic transmission. Evidence exhibits that HCN channels participate in pain and other physiological and pathological process. Pharmacological treatment targeting HCN channels is of benefit to relieve pain and other related diseases.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Douleur
/
Physiologie
/
Canaux potassiques
/
Transmission synaptique
/
Canaux contrôlés par les nucléotides cycliques et activés par l'hyperpolarisation
/
Potentiels de membrane
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Acta Physiologica Sinica
Année:
2014
Type:
Article
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