Progress on PI3K/Akt signaling pathway regulating self-renewal and pluripotency of embryonic stem cells / 生理学报
Acta Physiologica Sinica
;
(6): 223-230, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-297497
ABSTRACT
The phosphatidylinositol 3-kinase (PI3K) and its downstream target protein kinase B (Akt/PKB) can be activated by a variety of extracellular and intracellular signals. They are important signaling molecules and key survival factors involved in cell proliferation, differentiation, apoptosis and other cellular processes. Recently, many reports demonstrate that type I PI3K/Akt signaling pathway plays an important role in maintenance of self-renewal and pluripotency of embryonic stem (ES) cells. Further studies with regard to the self-renewal and pluripotency of ES cells and underlying molecular mechanisms are crucial to its application in cell replacement therapy, regenerative medicine and tissue engineering. The present review focuses on the recent progress on the mediation of PI3K/Akt signaling pathway on the maintenance of self-renewal and pluripotency of ES cells.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Physiologie
/
Transduction du signal
/
Différenciation cellulaire
/
Phosphatidylinositol 3-kinases
/
Biologie cellulaire
/
Cellules souches pluripotentes
/
Prolifération cellulaire
/
Protéines proto-oncogènes c-akt
/
Cellules souches embryonnaires
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Acta Physiologica Sinica
Année:
2014
Type:
Article
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