Progress in methodology of establishing physiologically based pharmacokinetic models / 药学学报
Acta Pharmaceutica Sinica
;
(12): 16-22, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-297977
ABSTRACT
Physiologically based pharmacokinetic model (PBPK), a mechanistic mathematic model, which can simulate the absorption, distribution, metabolism and excretion of drugs, is being more widely used in pharmaceutical research and development areas. This article reviews primarily the recent advances in the procedure of establishing a PBPK model, including specifying of the PBPK model structure, specification of the tissue model, writing of equations, set of model parameters, simulation and evaluation. Application significance, major challenges and future developments of PBPK model in pharmaceutical areas are also discussed.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Transport biologique
/
Simulation numérique
/
Logiciel
/
Pharmacocinétique
/
Préparations pharmaceutiques
/
Distribution tissulaire
/
Chimie
/
Métabolisme
/
Modèles biologiques
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2014
Type:
Article
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