Repeated injection of mitoxantrone containing thermosensitive liposomes in rat induced ABC phenomenon / 药学学报
Acta Pharmaceutica Sinica
;
(12): 256-259, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-297983
ABSTRACT
To investigate whether accelerated blood clearance (ABC) phenomenon could be induced after repeated injection of mitoxantrone thermosensitive liposomes, LC-MS/MS and enzyme linked immunosorbent assay (ELISA) were used to measure the concentration of mitoxantrone and the anti-polyethylene glycol (PEG) IgM levels in rat plasma, separately. The drug was rapidly cleared away after the second administration. The anti-PEG IgM was detected after the first dose which was neutralized quickly after the second dose. It is proved that repeated administration of mitoxantrone thermosensitive liposomes in rat caused the ABC phenomenon.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polyéthylène glycols
/
Sang
/
Immunoglobuline M
/
Pharmacocinétique
/
Taux de clairance métabolique
/
Chimie
/
Chromatographie en phase liquide à haute performance
/
Mitoxantrone
/
Rat Wistar
/
Spectrométrie de masse ESI
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2014
Type:
Article
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