Cyclooxygenases, lipoxygenases, their targeted drugs and the prevention of Alzheimer's disease / 药学学报
Acta Pharmaceutica Sinica
; (12): 1743-1754, 2013.
Article
de Zh
| WPRIM
| ID: wpr-298015
Bibliothèque responsable:
WPRO
ABSTRACT
Many studies have shown that chronic inflammation occurs in the brain of patients with Alzheimer's disease (AD). It is well known that long-term administration of non-steroidal anti-inflammatory drugs (NSAIDs) can alleviate the cognitive decline of AD patient and elderly. Several inflammatory cytokines produced in the metabolism of arachidonic acid (AA) are closely related to inflammatory diseases. Lipoxygenases (LOXs) and cyclooxygenases (COXs) play a crucial role in the AA network, the products eicosanoids have an important impact on the progression of AD. Although there are many arguments and conflicting evidence, currently LOXs and COXs are still the hot topics in the research on AD pathogenesis and drug development. Here, we review the progress in research on COXs and LOXs, including their actions on CNS and their association with AD, and explore the feasibility of LOXs and COXs as targets for the drugs to prevent and/or treat AD.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
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Encéphale
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Anti-inflammatoires non stéroïdiens
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Peptides bêta-amyloïdes
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Inhibiteurs de la lipoxygénase
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Inhibiteurs des cyclooxygénases
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Acide arachidonique
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Prostaglandin-endoperoxide synthases
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Prostaglandine H2
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Utilisations thérapeutiques
Limites du sujet:
Animals
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Humans
langue:
Zh
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2013
Type:
Article