Epigenetic research progress of anti-tumor drugs / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1629-1636, 2013.
Article
Dans Chinois
| WPRIM
| ID: wpr-298033
ABSTRACT
Epigenetic abnormalities not only associated with carcinogenesis, they may also influence the curative effect and prognosis of anticancer drugs through modifying pharmacokinetic genes related to drug absorption, distribution, metabolism, excretion and pharmacodynamic genes related to signaling pathways and targets. That drugs through regulating epigenetic factors pocessing anti-cancer effect is becoming a research hot spot. We summarized and analyzed the realtionship of DNA methylation, miRNA, and histone modification with antitumor drug effect, aiming at promoting rational use of antitumor drugs and providing new ideas on developing epi-drugs.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Histone
/
Méthylation de l'ADN
/
MicroARN
/
Utilisations thérapeutiques
/
Épigenèse génétique
/
Traitement médicamenteux
/
Génétique
/
Métabolisme
/
Tumeurs
/
Antinéoplasiques
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2013
Type:
Article
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