Expression of microRNA-10a-5p in laryngeal epithelial premalignant lesions / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 184-188, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-298082
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of microRNA-10a-5p (miR-10a) in laryngeal epithelial premalignant lesions (LEPL) and to analyze the correlations of its dysregulation with clinicopathologic parameters of LEPL.</p><p><b>METHODS</b>According to the WHO classification (2005), 94 cases of LEPL were grouped into mild dysplasia (MID), moderate dysplasia (MOD), severe dysplasia (SD) and carcinoma in situ ( CIS). The expression of miR-10a in 94 cases of LEPL was detected by quantitative real-time polymerase chain reaction (qRT-PCR), and correlated with the clinical and follow-up data of all LEPL patients.</p><p><b>RESULTS</b>miR-10a was down-regulated in LEPL with increasing grade of dysplasia. There was significantly statistical difference between low-risk ( MID + MOD) and high-risk ( SD + CIS) lesion groups (P = 0.03). The linear regression analysis showed that miR-10a was correlated with grade and gender of LEPL (P < 0.05).</p><p><b>CONCLUSIONS</b>Down regulation of miR-10a may be a useful molecular marker for grading of LEPL and diagnosis of early laryngeal cancer.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
États précancéreux
/
ARN tumoral
/
Épithélioma in situ
/
Marqueurs biologiques
/
Régulation négative
/
Tumeurs du larynx
/
MicroARN
/
Réaction de polymérisation en chaine en temps réel
/
Hyperplasie
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Pathology
Année:
2015
Type:
Article
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