Value of prostate specific antigen in early diagnosis of prostatic cancer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 107-112, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-298228
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the value of serum prostate specific antigen (PSA), free PSA (FPSA) and PSA density (PSAD) in early diagnosis of prostatic cancer.</p><p><b>METHODS</b>Sixty-eight patients with benign prostate hyperplasia (BPH), 28 with prostatic intraepithelial neoplasia (PIN) without canceration, and 32 with prostatic cancer, all diagnosed by prostatic biopsy, were enrolled in this study. Serum PSA and FPSA were measured and FPSA/PSA ratio and PSAD calculated for each patient, and the data analyzed to explore the association of these indices with prostatic cancer.</p><p><b>RESULTS</b>Serum PSA level and PSAD were markedly different between the cancer patients and non-cancer patients (P<0.001 and P<0.01, respectively). FPSA/PSA ratio also differed between them (P<0.05). The same results were also found between BPH and cancer patients. Significant difference was noted in serum PSA and PSAD between PIN and cancer patients (P<0.01), but not in FPSA/PSA ratio (P>0.05). No marked difference was observed in serum PSA, FPSA/PSA ratio and PSAD between BPH and PIN patients.</p><p><b>CONCLUSION</b>Serum PSA provides a very important clue for early diagnosis of prostatic cancer, and more accurate diagnosis can be obtained by considering also FPSA/PSA ratio. PSAD may also assist in the early diagnosis of prostatic cancer.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tumeurs de la prostate
/
Sang
/
Marqueurs biologiques tumoraux
/
Valeur prédictive des tests
/
Antigène spécifique de la prostate
/
Diagnostic précoce
/
Diagnostic
Type d'étude:
Etude diagnostique
/
Étude de dépistage
Limites du sujet:
Adulte très âgé
/
Aged80
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2007
Type:
Article
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