Value of coagulation function and fibrinolytic system assessment in patients with gestational diabetes mellitus / 南方医科大学学报
Journal of Southern Medical University
;
(12): 35-37, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-298250
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinical implications of changes of coagulation function and fibrinolytic system in patients with gestational diabetes mellitus (GDM).</p><p><b>METHODS</b>Twenty non-pregnant women, 20 with normal pregnancy and 46 with GDM were enrolled in this study for examinations of platelet alpha-granule membrane protein (GMP-140), Von Willebrand factor (vWF), antithrombin III activity (AT-III), plasminogen activity (PLG), activity of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI).</p><p><b>RESULTS</b>vWF, GMP-140, PLG, D-dimer, PAI were obviously elevated while t-PA was lower in GDM patients as compared with the measurement in non-pregnant women and women with normal pregnancy (P<0.01). AT-III and ProC measurement showed no significant differences between GDM patients and women of the other two groups.</p><p><b>CONCLUSION</b>GDM patients may have elevated platelet activation and fibrinolyic activity as well as vascular endothelial injuries, and antenatal assessment of the coagulation function can be of value for prevention and treatment of GDM.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Physiologie
/
Troisième trimestre de grossesse
/
Sang
/
Coagulation sanguine
/
Produits de dégradation de la fibrine et du fibrinogène
/
Facteur de von Willebrand
/
Endothélium vasculaire
/
Activation plaquettaire
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Diabète gestationnel
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Activateur tissulaire du plasminogène
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Grossesse
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2007
Type:
Article
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