The expression of human macrophage metalloelastase mRNA in gastric cancer cell lines and tissues and its clinical significance / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 830-832, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-298501
ABSTRACT
<p><b>OBJECTIVE</b>To make measurement of the expression of HME mRNA in both gastric cancer cell lines and tissues and evaluate its role in development of gastric cancer.</p><p><b>METHODS</b>The HME mRNA expression in 3 gastric cancer cell lines and tissues was detected by real-time fluorescent quantitative PCR.</p><p><b>RESULTS</b>All three gastric cancer cell lines expressed HME mRNA, and the HME mRNA expression level in gastric cancer tissues was higher than that in normal tissues (P <0.05). The rate of lymph node metastasis of HME mRNA positive cases was lower than that of HME mRNA negative ones (P < 0.05). Expression of drug resistance gene GST of HME mRNA positive cases was lower than that of HME mRNA negative ones (P <0.05). The two-year survival rate of HME mRNA positive cases was higher than that of HME mRNA negative ones (P < 0.05). There was no correlation between the expression of HME gene and the tumor location, size, depth of invasion, degree of malignancy, expression of drug resistance gene top II and PG.</p><p><b>CONCLUSION</b>The expression of HME gene in gastric cancers may be related with lower possibility of metastasis and predict a better prognosis.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Tumeurs de l'estomac
/
ARN messager
/
Taux de survie
/
Études de suivi
/
Lignée cellulaire tumorale
/
Matrix metalloproteinase 12
/
Muqueuse gastrique
/
Génétique
/
Glutathione transferase
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Oncology
Année:
2007
Type:
Article
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