Expression and biological significance of HPA and HIF-1alpha in human esophageal squamous cell carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 689-692, 2007.
Article
de Zh
| WPRIM
| ID: wpr-298517
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of HPA and HIF-1alpha in human esophageal squamous cell carcinoma and their relationship with cancer development, invasion and metastasis.</p><p><b>METHODS</b>The expression of HPA mRNA and HIF-1alpha protein in 23 mucosa specimens of incisal margin, 26 para-tumorous dysplastic tissues and 70 esophageal squamous cell carcinoma specimens were detected by in situ hybridization assay and immunohistochemical staining, respectively.</p><p><b>RESULTS</b>The positive expression of HPA mRNA and HIF-1alpha protein were significantly increased as the epithelial cells progressed into carcinoma (P < 0.05). The expression of HPA mRNA and HIF-1alpha protein in the esophageal squamous cell carcinoma were significantly correlated with the invasion depth, lymph node metastasis and clinical staging (P < 0.05), while it was not correlated with the differentiation of tumors (P > 0.05). There was a close correlation between the expression of HPA mRNA and HIF-1alpha protein in the carcinoma tissues (P < 0.01).</p><p><b>CONCLUSION</b>The high expression of HPA mRNA and HIF-1alpha protein is correlated with carcinogenesis, progression, invasion and metastasis of esophageal squamous cell carcinoma. There may be a positive cooperation between two of them in the carcinogenesis and development of esophageal carcinoma. The determination of HPA mRNA and HIF-1 alpha will be useful in predicting tumor biological behavior.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
/
ARN messager
/
Tumeurs de l'oesophage
/
Immunohistochimie
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Carcinome épidermoïde
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Régulation de l'expression des gènes tumoraux
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Hybridation in situ
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Oesophage
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Sous-unité alpha du facteur-1 induit par l'hypoxie
/
Génétique
Type d'étude:
Prognostic_studies
Limites du sujet:
Adult
/
Aged
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Female
/
Humans
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Oncology
Année:
2007
Type:
Article