Transhepatic arterial chemoembolization by epirubicin mixed with microspheres for hepatocellular carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 619-622, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-298535
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the safety and efficacy of transhepatic arterial infusion of the mixture of epirubicin and microspheres as the embolization materials for treatment of patients with hepatocellular carcinoma (HCC).</p><p><b>METHODS</b>The mixture was made of 10-60 mg epirubicin (Pfizer) mixed with 300-500 microm microspheres in 0.5-2 ml (Contour SE Boston Scientific), which was used for embolizating the artery supplying HCC. Changes of leucocyte counts, liver function, serum AFP level, response of tumor to TACE and complications related to embolization were analyzed before and after TACE.</p><p><b>RESULTS</b>136 HCC patients (male/female 91/45, mean age 54.8 +/- 13.3 years) were studied. After TACE, the liver function was damaged and tumor size shrunken significantly (P < 0.05).</p><p><b>CONCLUSION</b>Transhepatic arterial chemoembolization using the mixture of epirubicin and microspheres for embolizating is safe and effective for the treatment of HCC, but the amount of embolization material should be chosen carefully in order to avoid liver function failure.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Aspartate aminotransferases
/
Thérapeutique
/
Sang
/
Sérumalbumine
/
Épirubicine
/
Alphafoetoprotéines
/
Taux de survie
/
Études de suivi
/
Chimioembolisation thérapeutique
/
Carcinome hépatocellulaire
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Oncology
Année:
2007
Type:
Article
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