Prognostic factors of invasive non-Hodgkin's lymphoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 461-463, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-298575
ABSTRACT
<p><b>OBJECTIVE</b>There is heterogeneity in non-Hodgkin's lymphoma. The purpose of this study is to investigate the prognostic factors of invasive non-Hodgkin's lymphoma.</p><p><b>METHODS</b>From June 2002 to June 2006, 137 patients with invasive non-Hodgkin's lymphoma were treated by regular regimen consisting of radiotherapy and chemotherapy. The clinical data including prognostic factors was analyzed by SPSS 10.0.</p><p><b>RESULTS</b>After treated with chemotherapy and radiotherapy, 35 (25.5%) patients achieved CR, 67 (48.9%) PR, 6 (4.3%) SD, 29 (21.2%) PD, ORR (objective response rate) of this series was 74.5%. The overall 4-year survival rate was 70.8%. The PFS (prognosis free survival) was 42.7%. Multivariate analysis using Cox model indicated that clinical stage III-IV, PS score > or = 2, more than 2 external nodal involvement were closely correlated with overall survival.</p><p><b>CONCLUSION</b>The overall survival of invasive non-Hodgkin's lymphoma treated with present combined therapy regimen has been improved greatly. However, further investigation is still needed for exploring more effective individualized treatment regimen.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pronostic
/
Radiothérapie
/
Vincristine
/
Lymphome malin non hodgkinien
/
Induction de rémission
/
Prednisone
/
Protocoles de polychimiothérapie antinéoplasique
/
Doxorubicine
/
Modèles des risques proportionnels
Type d'étude:
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Aged80
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Oncology
Année:
2007
Type:
Article
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