The expression of vascular endothelial growth factor, CD44v6 in non-small cell lung carcinoma / 中华外科杂志
Chinese Journal of Surgery
;
(12): 647-650, 2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-299872
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of vascular endothelial growth factor (VEGF), CD44v6 in non-small cell lung carcinoma.</p><p><b>METHODS</b>The expression of VEGF and CD44v6 in 35 cases I approximately II stages, 27 cases III approximately IV stages and 50 cases with the metastasis of lymph nodes, 12 cases without metastasis of non-small cell lung carcinoma (NSCLC) tissues were studied by SP immunohistochemistry staining, and the 3 years survival rates were calculated in 42 cases patients.</p><p><b>RESULTS</b>The positive rates of VEGF and CD44v6 in NSCLC were 73% and 69%, respectively. They were both higher than those of matched normal lung tissues, P < 0.01. The expression of VEGF and CD44v6 were related to clinical stages and metastasis of lymph nodes significantly. The expression rates of the two markers in NSCLC with the metastasis of lymph nodes were higher than those without metastasis, chi(2) = 7.146 and 5.376 respectively, and those of III approximately IV stages were higher than those of I approximately II Stages, chi(2) = 6.392 and 12.152 respectively. Survival rates of three years were lower to those patients with positive expression of the two makers than those with negative expression. In a multivariate analysis, besides TNM stages and metastasis of lymph nodes, the positive expression of CD44v6 and the positive expression of VEGF were also the independent prognostic factors to affect the Survival time.</p><p><b>CONCLUSION</b>The VEGF and CD44v6 protein may act as one of important indexes to indicate the process of infiltration and metastasis in NSCLC.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Modèles des risques proportionnels
/
Taux de survie
/
Études de suivi
/
Mortalité
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Carcinome pulmonaire non à petites cellules
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Antigènes CD44
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Facteur de croissance endothéliale vasculaire de type A
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Tumeurs du poumon
/
Noeuds lymphatiques
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Surgery
Année:
2004
Type:
Article
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