Community-associated methicillin-resistant Staphylococcus aureus: overview and local situation
Annals of the Academy of Medicine, Singapore
;
: 479-486, 2006.
Article
Dans Anglais
| WPRIM
| ID: wpr-300076
ABSTRACT
<p><b>INTRODUCTION</b>Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has emerged worldwide. In contrast to healthcare-associated MRSA (HA-MRSA), CA-MRSA isolates are usually susceptible to multiple non-beta-lactam antibiotics and cause a distinct spectrum of infections in epidemiologically disparate populations - in particular, cutaneous abscesses, necrotising fasciitis and necrotising pneumonia. They arise from a broader genetic background, and possess differing virulence genes. We aim to describe the distribution of different molecular subtypes of CA-MRSA among various regions and discuss briefly the implications of CA-MRSA from a local perspective.</p><p><b>METHODS</b>Literature review of articles on CA-MRSA, focusing mainly on reports where the genetic background of isolates had been analysed using multi-locus sequence typing (MLST). Singapore data were obtained from the local CA-MRSA database.</p><p><b>RESULTS</b>MLST analysis demonstrated the presence of epidemic subtypes of CA-MRSA within most geographic areas. In parts of the United States, community MRSA infections currently exceed those caused by their methicillin-susceptible counterparts. In Singapore, CA-MRSA infections are increasing, predominantly as a result of the spread of ST30 clones.</p><p><b>CONCLUSION</b>Available evidence suggests that the emergence of MRSA from the community is not going to be a transient phenomenon. Local guidelines for dealing with this phenomenon at both therapeutic and preventive levels are needed prior to the potential development of a situation mirroring that of meso-endemic HA-MRSA in local hospitals or CA-MRSA epidemics in parts of USA.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Singapour
/
Infections à staphylocoques
/
Staphylococcus aureus
/
Infection croisée
/
Épidémiologie
/
Facteurs de risque
/
Résistance à la méticilline
/
Techniques de typage bactérien
/
Classification
/
Infections communautaires
Type d'étude:
Etude diagnostique
/
Etude d'étiologie
/
Guide de pratique
/
Facteurs de risque
Limites du sujet:
Humains
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Annals of the Academy of Medicine, Singapore
Année:
2006
Type:
Article
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