Potentially fatal paracetamol overdose and successful treatment with 3 days of intravenous N-acetylcysteine regime--a case report
Annals of the Academy of Medicine, Singapore
;
: 108-111, 2006.
Article
Dans Anglais
| WPRIM
| ID: wpr-300142
ABSTRACT
<p><b>INTRODUCTION</b>Paracetamol overdose is the most common drug overdose worldwide. To our knowledge, the maximum number of paracetamol tablets ingested reported in the literature is 45 g.</p><p><b>CLINICAL PICTURE</b>We describe a 21-year-old patient who acutely ingested 120 tablets, each 500 mg paracetamol (i.e., 60 g equivalent to 1200 mg/kg body weight) in a suicidal attempt. Our patient also drank 2 bottles of codeine-based cough syrup equivalent to 360 mg of codeine. At 6 hours post ingestion, her serum paracetamol level was 207 mg/L. The poor prognostic factors for paracetamol overdose in our patient included massive paracetamol ingestion (confirmed by blood levels), codeine co-ingestion and elevated serum amylase (189 U/L).</p><p><b>TREATMENT</b>She was treated with a 3-day modified regimen of intravenous N-acetylcysteine.</p><p><b>OUTCOME</b>The liver function tests and the prothrombin time remained normal over the second and third day of admission and the patient was discharged without complications on the fifth day.</p><p><b>CONCLUSION</b>From this experience we feel that in very severe paracetamol poisoning, a modified regime of intravenous N- acetylcysteine for 3 days is safe and efficacious.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Intoxication
/
Acétylcystéine
/
Tentative de suicide
/
Comprimés
/
Facteurs temps
/
Sang
/
Codéine
/
Mauvais usage des médicaments prescrits
/
Amylases
/
Tests de la fonction hépatique
Type d'étude:
Étude pronostique
Limites du sujet:
Adulte
/
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Annals of the Academy of Medicine, Singapore
Année:
2006
Type:
Article
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