The Influence of Iron Deficiency on Helicobacter pylori Eradication
The Korean Journal of Helicobacter and Upper Gastrointestinal Research
;
: 82-87, 2016.
Article
Dans Anglais
| WPRIM
| ID: wpr-30053
ABSTRACT
BACKGROUND/AIMS:
Helicobacter pylori is a distinctive pathogen that lives in the gastric mucosa and is a well known risk factor of gastric adenocarcinoma. Iron deficiency aggravates the development of H. pylori-induced premalignant and malignant lesions in a cagA-dependent manner, enhancing H. pylori virulence. The aim of this study was to identify the relationship between iron deficiency and H. pylori eradication rates. MATERIALS ANDMETHODS:
Participants who received 7 days of first-line triple therapy with serum iron level measured in parallel were retrospectively investigated between 2005 and 2014. H. pylori eradication was confirmed by the rapid urease test or 13C-urea breath test at least 4 weeks after completion of triple therapy. Iron deficiency was defined as either a serum iron level less than 50 µg/dL or a serum ferritin level less than 12 ng/mL.RESULTS:
A total of 194 patients received 7 days of first-line triple therapy along with parallel serum iron level measurements over the 10-year period. The mean average age was 53.3 years (range, 21~86 years), and 135 patients (69.6%) were male. The overall H. pylori eradication rate was 83.5%. Proportions of eradication success with ferritin level less than 12 ng/mL and iron less than 50 µg/dL were 90.5% and 88.6%, respectively. However, there was no statistical difference in eradication rates according to iron deficiency.CONCLUSIONS:
Iron deficiency might not be related with H. pylori eradication rates in this study. Further large-scale studies are needed to confirm this result.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Urease
/
Virulence
/
Tests d'analyse de l'haleine
/
Adénocarcinome
/
Études rétrospectives
/
Facteurs de risque
/
Helicobacter pylori
/
Helicobacter
/
Ferritines
/
Éradication de maladie
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
The Korean Journal of Helicobacter and Upper Gastrointestinal Research
Année:
2016
Type:
Article
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