Therapeutic efficiency of amphotericin B liposome modified by RMP-7 to transport drug across blood brain barrier / 药学学报
Acta Pharmaceutica Sinica
;
(12): 292-295, 2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-301092
ABSTRACT
<p><b>AIM</b>To study the therapeutic efficiency of amphotericin B liposome (AmB-L) targeting to the brain in mice with meningitis.</p><p><b>METHODS</b>Amphotericin B liposome targeting to the brain were prepared by film-sonication method. Their concentration and encapsulation percentage were determined. The Candida albicans was injected into the brain of BALB/c mice and the meningitis model was set up. Then the therapeutic efficiency of amphotericin B liposome targeting to the brain was studied.</p><p><b>RESULTS</b>The encapsulation percentage of amphotericin B liposome was 93.3%. The meningitis model was set up after the Candida albicans was injected into the brain of BALB/c mice for 2 h. The therapeutic efficiency was increased after conjugating RMP-7 (the commercial nama is Cereport) to the surface of amphotericin B liposome.</p><p><b>CONCLUSION</b>The therapeutic efficiency of Amphotericin B liposome targeting to the brain in the mice with meningitis was better than that of the common amphotericin B liposome and the life of the mice in AmB-L-PEG-RMP-7 group was longer than that of the mice in AmB-L-PEG group and AmB-L-PEG + RMP-7 group.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Transport biologique
/
Encéphale
/
Candida albicans
/
Bradykinine
/
Pharmacocinétique
/
Barrière hémato-encéphalique
/
Amphotéricine B
/
Méningite fongique
/
Systèmes de délivrance de médicaments
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2004
Type:
Article
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