Comparison of efficacy and adverse effects between arsenic trioxide and all-trans retinoic acid in patients with acute promyelocytic leukemia / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 555-558, 2009.
Article
de Zh
| WPRIM
| ID: wpr-301653
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare the efficacy and adverse effects between arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) in patients with acute promyelocytic leukemia (APL).</p><p><b>METHODS</b>The clinical data of 71 patients with newly diagnosed APL were retrospectively analyzed. Two groups were classified according to the induction regimens, namely ATO group (n = 41) and ATRA group (n = 30). The complete remission (CR) rate and the time to CR were compared between these two groups.</p><p><b>RESULTS</b>The CR rate was 97.5% in ATO group and 93.3% in ATRA group (P > 0.05). The median time to CR was 29 days (21-45 days) in ATO group, which was significantly shorter than 38.5 days (24-63 days) in ATRA group (P < 0.001). Retinoic acid syndrome occurred in 52.9% of patients treated with ATRA, which affected the further use of ATRA.</p><p><b>CONCLUSIONS</b>Both ATO and ATRA have high response rates for newly diagnosed patients with APL. Compared with ATRA, ATO induction therapy has shorter time to achieve CR and less adverse effects, and therefore may be the first-line therapy for APL.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Oxydes
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Composés de l'arsenic
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Trétinoïne
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Induction de rémission
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Leucémie aiguë promyélocytaire
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Études rétrospectives
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Résultat thérapeutique
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Utilisations thérapeutiques
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Traitement médicamenteux
Type d'étude:
Observational_studies
Limites du sujet:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Acta Academiae Medicinae Sinicae
Année:
2009
Type:
Article