Research progress on MAPK signal pathway in the pathogenesis of osteoarthritis / 中国骨伤
China Journal of Orthopaedics and Traumatology
;
(12): 441-444, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-301797
ABSTRACT
Mitogen-activated protein kinases (MAPKs) signal is one of the important ways in eukaryotic cell,which adjusts and controls the structure and function of the cell. MAPKs in eukaryotes include p38, ERK, JNK and ERK5, etc. With the deepening research,we found that the activation of p38, ERK, JNK signal pathways were closely related with osteoarthritis (OA) cartilage injury. MAPKs are the key signaling systems involved in the production of matrix metalloproteinases and the regulation of cartilage cell proliferation, apoptosis and differentiation. Expecially the matrix metalloproteinases can accelerate the degradation of articular cartilage. So it has been the new spot in pathogenesis of osteoarthritis study.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Arthrose
/
Anatomopathologie
/
Cartilage articulaire
/
Mitogen-Activated Protein Kinases
/
Système de signalisation des MAP kinases
/
Métabolisme
Type d'étude:
Etude d'étiologie
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
China Journal of Orthopaedics and Traumatology
Année:
2014
Type:
Article
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