The construction of two kinds of artificial bone and the comparison of their osteogenesis capability in vivo / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 17-21, 2003.
Article
Dans Chinois
| WPRIM
| ID: wpr-301908
ABSTRACT
<p><b>OBJECTIVE</b>To construct artificial bone with collagen-hydroxyapatite (HA) or collagen-HA-chondroitin sulfate (CS) as the scaffolds, and observe their biological properties.</p><p><b>METHODS</b>The artificial bones were constructed by attaching recombinant human bone morphogenetic protein 2 (rhBMP-2) on those scaffolds. And then they were embedded into muscles of rats. Every weekend those newly formed bones were taken from muscles for comparing the difference in osteogenetic capability of two kinds of artificial bone in vivo.</p><p><b>RESULTS</b>Both kinds of artificial bones could induce bone regeneration in muscle. The collagen-HA-CS artificial bone was superior to the collagen-HA artificial in bone-guided degree.</p><p><b>CONCLUSIONS</b>The CS could promote the form action of new bone and accelerate the bone healing.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ostéoblastes
/
Ostéogenèse
/
Pharmacologie
/
Matériaux biocompatibles
/
Régénération osseuse
/
Chondroïtines sulfate
/
Facteur de croissance transformant bêta
/
Collagène
/
Substituts osseux
/
Protéines morphogénétiques osseuses
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Acta Academiae Medicinae Sinicae
Année:
2003
Type:
Article
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