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Synergistic effect of toremifene and cisplatin on human lung cancer cell line A549 / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 537-539, 2002.
Article Dans Chinois | WPRIM | ID: wpr-301942
ABSTRACT
<p><b>OBJECTIVE</b>To study the toxic effect of toremifene (TOR) and its synergistic effect with cisplatin (DDP) on human lung adenocarcinoma cell line A549.</p><p><b>METHODS</b>The cytotoxic effects of these agents on human lung cancer cell line A549 were monitored by a tetrazolium-based colorimetric assay (MTT assay). The cell cycle and DNA content were detected by flow cytometer technic. p21 expression level was monitored by Western blot.</p><p><b>RESULTS</b>Toremifene inhibited the growth of A549 cell, with > or = 5 micromol/L significantly enhancing the chemosensitivity of cisplatin. TOR enhanced the antitumor activity of DDP at S, G(2) and M phases of cells. And p21 expression was increased after TOR and DDP had been given.</p><p><b>CONCLUSION</b>Toremifene (> or = 5 micromol/L) combined with cisplatin shows significant synergistic anti-tumor effect on A549 cells.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Anatomopathologie / Pharmacologie / Tests de criblage d&apos;agents antitumoraux / Cellules cancéreuses en culture / Protocoles de polychimiothérapie antinéoplasique / Division cellulaire / Cisplatine / Torémifène / Résistance aux médicaments antinéoplasiques / Synergie des médicaments Limites du sujet: Humains langue: Chinois Texte intégral: Chinese Journal of Oncology Année: 2002 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Anatomopathologie / Pharmacologie / Tests de criblage d&apos;agents antitumoraux / Cellules cancéreuses en culture / Protocoles de polychimiothérapie antinéoplasique / Division cellulaire / Cisplatine / Torémifène / Résistance aux médicaments antinéoplasiques / Synergie des médicaments Limites du sujet: Humains langue: Chinois Texte intégral: Chinese Journal of Oncology Année: 2002 Type: Article