Acute biphenotypic leukemia in the adults / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 375-377, 2002.
Article
Dans Anglais
| WPRIM
| ID: wpr-302007
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinical, biological features and prognosis of acute biphenotypic leukemia (BAL) in the adults.</p><p><b>METHODS</b>Bone marrow specimens of 63 BAL patients were evaluated to prove the diagnosis and the classification by morphologic, cytochemical, immunologic and cytogenetic (MIC) examinations. These patients were treated with protocols suitable for acute myeloid leukemia (AML), or acute lymphoblastic leukemia (ALL), or both.</p><p><b>RESULTS</b>No significant difference in clinical features was observed between BAL, AML or ALL. Morphologically, the subtypes of M(5), M(1) and M(2) were predominant in AML, as L(2) and L(1) were in ALL. Immunologically, coexpression of myeloid and B lineage associated antigens was predominant and CD(34) was hyperexpressed in BAL, which suggested that BAL might originate from malignant transformation of earlier hematopoietic cells. Cytogenetically, Ph chromosome was observed in 25.5% (13/51) of BAL patients. Prognostically, both the treatment response and the overall survival of BAL patients were poor.</p><p><b>CONCLUSION</b>Patients with BAL have unique clinical, biological and prognostic features.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Leucémie myéloïde
/
Maladie aigüe
/
Cytogénétique
/
Traitement médicamenteux
/
Allergie et immunologie
/
Leucémie-lymphome lymphoblastique à précurseurs B et T
/
Génétique
Type d'étude:
Guide de pratique
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Aged80
/
Enfant
/
Enfant d'âge préscolaire
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Chinese Journal of Oncology
Année:
2002
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS