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Deletions of derivative chromosome 9 in 138 patients with chronic myeloid leukemia / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 281-284, 2009.
Article Dans Chinois | WPRIM | ID: wpr-302148
ABSTRACT
To investigate the frequency of derivative chromosome 9 [der (9)] deletions in patients with chronic myelogenous leukemia (CML), karyotype analysis in 138 patients with CML was performed with R-banding technique, and dual fusion fluorescence in situ hybridization (FISH) was used to detect der (9) deletion. The results showed that among 138 cases, 126 cases were Ph positive (91.3%) from which 122 cases were typical Ph translocation, 12 cases were Ph negative (8.7%). FISH detection revealed 23 with der (9) deletions out of 138 cases (16.7%), 20 out of 122 cases with typical Ph translocation showed typical Ph translocation (16.4%) and 3 out of 4 cases with variant Ph translocation had variant Ph translocation (75%). 20 cases were in chronic phase (CP) (17.2%), 3 cases were in blast crisis (BC) (17.6%), there was no significant difference in the frequency of the der (9) deletions between the cases in CP and in BC (p < 0.05). It is concluded that incidence of der (9) partial deletions in CML patients is 16.7%, FISH can effectively detect the der (9) deletions, and there is no correlation of der (9) deletion frequency between cases in different phases of CML.
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Chromosomes humains de la paire 9 / Leucémie myéloïde chronique BCR-ABL positive / Délétion de segment de chromosome / Délétion de séquence / Hybridation fluorescente in situ / Diagnostic / Génétique / Caryotypage / Méthodes Type d'étude: Etude diagnostique Limites du sujet: Adolescent / Adulte / Adulte très âgé / Aged80 / Femelle / Humains / Mâle langue: Chinois Texte intégral: Journal of Experimental Hematology Année: 2009 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Chromosomes humains de la paire 9 / Leucémie myéloïde chronique BCR-ABL positive / Délétion de segment de chromosome / Délétion de séquence / Hybridation fluorescente in situ / Diagnostic / Génétique / Caryotypage / Méthodes Type d'étude: Etude diagnostique Limites du sujet: Adolescent / Adulte / Adulte très âgé / Aged80 / Femelle / Humains / Mâle langue: Chinois Texte intégral: Journal of Experimental Hematology Année: 2009 Type: Article