Expressions of vascular endothelial growth factor and cyclooxygenase-2 in patients with multiple myeloma and its significance / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 99-101, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-302189
ABSTRACT
This study was aimed to investigate the expressions of vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) in patients with multiple myeloma (MM) and its clinical significance. Expression of VEGF was detected by enzyme linked immunosorbent assay (ELISA) and the level of COX-2 was detected by Western blot. The results showed that the serum VEGF level of multiple myeloma patients (365.34 +/- 65.63 pg/ml) was higher than that in the normal persons (122.52 +/- 39.29 pg/ml) (p < 0.05); the serum VEGF level of patients at advanced stage (395.07 +/- 54.90) pg/ml was higher than those at stable stage (300.33 +/- 44.22) pg/ml (p < 0.05). The serum Cox-2 positive rate in the patients (31%) was higher than that in normal persons (0%) (p < 0.01); the serum Cox-2 positive rate in the patients at advanced stage (50%) was higher than those at stable stage (21%) (p < 0.01). It is concluded that VEGF and COX-2 may play an important role in the pathogenesis and development of multiple myeloma, they can be used to evaluate the status of patients with MM.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Sang
/
Études cas-témoins
/
Facteur de croissance endothéliale vasculaire de type A
/
Cyclooxygenase 2
/
Myélome multiple
Type d'étude:
Étude observationnelle
Limites du sujet:
Adulte
/
Adulte très âgé
/
Aged80
/
Humains
langue:
Chinois
Texte intégral:
Journal of Experimental Hematology
Année:
2009
Type:
Article
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