Studies on the influencing factors on the drug release from sodium alginate matrices / 药学学报

ABSTRACT

<p><b>AIM</b>To investigate the in vitro influencing factors on drug release from matrices with sodium alginate as the hydrophilic polymer.</p><p><b>METHODS</b>Sodium alginate hydrophilic matrix tablets were prepared by direct compression method with theopylline as a model drug. The in vitro influencing factors on drug release behavior from matrices were studied by investigating the swelling, water uptake and erosion characteristics of pure sodium alginate matrices.</p><p><b>RESULTS</b>The results showed that drug release rate and drug release mechanism were both related to the viscosity of sodium alginate used in matrices, pH values and ionic strength of dissolution media and rotation speeds.</p><p><b>CONCLUSION</b>Sodium alginate can be tailor-made to suit the demands of applicants in sustained delivery systems as a good candidate of hydrophilic polymer.</p>