Structural characterization of chlorobenzylidine / 药学学报
Acta Pharmaceutica Sinica
;
(12): 546-550, 2004.
Article
Dans Anglais
| WPRIM
| ID: wpr-302765
ABSTRACT
<p><b>AIM</b>To study the structure and crystal forms of chlorobenzylidine.</p><p><b>METHODS</b>Karl Fischer titrimetry, FTIR, thermal analysis, single and powder X-ray diffraction were used for the studies of the structure of chlorobenzylidine and for the identification of two forms of chlorobenzylidine.</p><p><b>RESULTS</b>Chlorobenzylidine and its diastereoisomer have been studied in this article. They can be distinguished by their different melting points. Two crystal forms of chlorobenzylidine (form A and form B) have also been detected and studied. Form A was studied by single-crystal X-ray diffraction, it crystallized in the triclinic system, space group P1(-), with two formula units per cell, is monohydrate. Karl Fischer titrimetry, FTIR, thermal analysis and powder X-ray diffraction were used for identification of the two forms.</p><p><b>CONCLUSION</b>The studies of structure and crystal forms of chlorobenzylidine are very useful for the clinical research and the selection of recrystallization process.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Composés polycycliques
/
Stéréoisomérie
/
Composés benzylidéniques
/
Structure moléculaire
/
Chimie
/
Cristallographie aux rayons X
/
Cristallisation
/
Analyse thermique différentielle
/
Conformation moléculaire
langue:
Anglais
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2004
Type:
Article
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