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Intravitreal Anti-vascular Endothelial Growth Factor for Typical Exudative Age-related Macular Degeneration in Eyes with Good Baseline Visual Acuity
Korean Journal of Ophthalmology ; : 466-472, 2014.
Article Dans Anglais | WPRIM | ID: wpr-30316
ABSTRACT

PURPOSE:

To investigate 12-month treatment outcomes of anti-vascular endothelial growth factor therapy in eyes with typical exudative age-related macular degeneration with good baseline visual acuity.

METHODS:

This retrospective observational case series included 18 eyes (18 patients) with typical exudative age-related macular degeneration with a baseline best-corrected visual acuity of 20 / 25 or better. Patients were treated with anti-vascular endothelial growth factor monotherapy during the 12-month follow-up period. Baseline visual acuity and central foveal thickness were compared to the values at 12 months.

RESULTS:

Patients received an average of 4.4 +/- 1.3 intravitreal anti-vascular endothelial growth factor injections. The mean logarithm of minimum angle of resolution visual acuity was 0.08 +/- 0.04, 0.08 +/- 0.07, 0.12 +/- 0.09, and 0.16 +/- 0.11 at baseline, three months, six months, and 12 months, respectively. Visual acuity at 12 months was significantly worse than the baseline value at diagnosis (p = 0.017), and the mean central foveal thickness at the defined time points was 270.2 +/- 55.6, 204.4 +/- 25.4, 230.1 +/- 56.3, and 216.8 +/- 48.7 microm, respectively. The central foveal thickness at 12 months was significantly less than the baseline value at diagnosis (p = 0.042).

CONCLUSIONS:

Deterioration in visual acuity was noted in eyes with typical exudative age-related macular degeneration with good baseline visual acuity, suggesting the need for close patient monitoring and prompt treatment even in patients with good baseline visual acuity.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Angiographie fluorescéinique / Acuité visuelle / Études rétrospectives / Néovascularisation choroïdienne / Inhibiteurs de l'angiogenèse / Facteur de croissance endothéliale vasculaire de type A / Tomographie par cohérence optique / Dégénérescence maculaire humide / Injections intravitréennes / Bévacizumab Type d'étude: Étude observationnelle Limites du sujet: Adulte très âgé / Femelle / Humains / Mâle langue: Anglais Texte intégral: Korean Journal of Ophthalmology Année: 2014 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Angiographie fluorescéinique / Acuité visuelle / Études rétrospectives / Néovascularisation choroïdienne / Inhibiteurs de l'angiogenèse / Facteur de croissance endothéliale vasculaire de type A / Tomographie par cohérence optique / Dégénérescence maculaire humide / Injections intravitréennes / Bévacizumab Type d'étude: Étude observationnelle Limites du sujet: Adulte très âgé / Femelle / Humains / Mâle langue: Anglais Texte intégral: Korean Journal of Ophthalmology Année: 2014 Type: Article