Efficacy and side effects of combination therapy of oxaliplatin and S-1 for colorectal cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 388-390, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-303289
ABSTRACT
<p><b>OBJECTIVE</b>To observe the efficacy and side effects of the combination therapy of oxaliplatin and S-1 in treating postoperative colorectal cancer patients.</p><p><b>METHODS</b>54 postoperative colorectal cancer patients received the combination therapy of oxaliplatin and S-1 regimen, repeated every 3 weeks, and evaluate the efficacy after 3 cycles.</p><p><b>RESULTS</b>All of the 54 patients but 2 (changed the chemotherapy regimen after the first cycle because of economic reason) finished 6 cycles of the chemotherapy treatment. There were 6 cases (11.5%) with complete response (CR), 28 cases (53.8%) with partial response (PR), and the overall response rate was 65.4%. Major adverse effects were hematological toxicities, gastrointestinal disturbance, neurosensory toxicity. There were no chemotherapy-related deaths.</p><p><b>CONCLUSIONS</b>Oxaliplatin combined with S-1 is an effective and better tolerated chemotherapy treatment for postoperative colorectal cancer patients, with no serious side effects for liver and kidney. Therefore, it can be used as an alternative chemotherapy regimen for postoperative colorectal cancer patients.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Composés organiques du platine
/
Acide oxonique
/
Période postopératoire
/
Pyridines
/
Tumeurs du rectum
/
Chirurgie générale
/
Vomissement
/
Induction de rémission
/
Adénocarcinome
/
Protocoles de polychimiothérapie antinéoplasique
Limites du sujet:
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Oncology
Année:
2011
Type:
Article
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