Neuroendocrine neoplasm of digestive system with different grades: a clinicopathologic and prognostic study / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 448-451, 2012.
Article
Dans Chinois
| WPRIM
| ID: wpr-303550
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinicopathologic and prognostic features of neuroendocrine neoplasm of digestive system with different grades.</p><p><b>METHODS</b>The clinicopathologic features of 139 cases of neuroendocrine neoplasm occurring in digestive system were retrospectively reviewed and graded according to the 2010 World Health Organization classification of tumours of the digestive system. Immunohistochemical study for synaptophysin, chromogranin A and Ki-67 was carried out. The follow-up and survival data were analysed using Kaplan-Meier method. Prognostic factors were tested by Log-rank testing and independent risk factors were analysed using Cox regression model.</p><p><b>RESULTS</b>Amongst the 139 cases studied, there were 88 cases (63.3%) of grade 1 tumors, 9 cases (6.5%) of grade 2 tumors and 42 cases (30.2%) of grade 3 tumors. There was diffusely positive staining for synaptophysin and chromogranin A in most of the grade 1 and grade 2 tumors. The staining in grade 3 tumors however was focal (P < 0.05). The differences in tumor size, depth of invasion, presence of tumor emboli, perineural permeation, nodal involvement, distant metastasis and survival rate amongst the three groups was statistically significant (P < 0.05).</p><p><b>CONCLUSIONS</b>There is significant difference in the clinicopathologic and prognostic features of neuroendocrine neoplasm of digestive system with different grades. It is considered as an independent prognostic factor and represents a useful tool for prognostic evaluation of such tumors, both in clinical practice and research.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Modèles des risques proportionnels
/
Taux de survie
/
Études rétrospectives
/
Études de suivi
/
Synaptophysine
/
Tumeurs neuroendocrines
/
Antigène KI-67
/
Charge tumorale
/
Tumeurs de l'appareil digestif
Type d'étude:
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adulte
/
Adulte très âgé
/
Aged80
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Pathology
Année:
2012
Type:
Article
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