Cytotoxicity of the rhizome of medicinal plants
Asian Pacific Journal of Tropical Biomedicine
;
(12): 125-127, 2012.
Article
Dans Anglais
| WPRIM
| ID: wpr-303613
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the cytotoxicity of the crude ethanol extract of the rhizome of Zingiber zerumbet (Z. zerumbet) (L) Smith. and Curcuma zedoaria (C. zedoaria) Rosc. against Artemia salina Leach.</p><p><b>METHODS</b>Fresh rhizomes of Z. zerumbet (L) Smith. and C. zedoaria Rosc. were extracted separately in cold with ethanol (2.5 L) and after concentration a brownish syrupy suspension of ethanol extracts of Z. zerumbet (L) Smith. and C. zedoaria Rosc. was obtained. The cytotoxic effect of the crude ethanol extracts of both plants was determined by brine shrimp lethality bioassay.</p><p><b>RESULTS</b>Crude ethanol extracts of the rhizome of Z. zerumbet (L) Smith. showed the highest cytotoxicity (LC50 was 1.24 µg/mL) against brine shrimp nauplii as compared with C. zedoaria Rosc. (LC50 was 33.593 µg/mL) after 24 h of exposure.</p><p><b>CONCLUSIONS</b>It can be concluded that the rhizome of Z. zerumbet (L) Smith. and C. zedoaria Rosc. can be used as a source of cytotoxic agent.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Plantes médicinales
/
Artemia
/
Extraits de plantes
/
Zingiberaceae
/
Curcuma
/
Rhizome
/
Toxicité
/
Phytothérapie
/
Métabolisme
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Asian Pacific Journal of Tropical Biomedicine
Année:
2012
Type:
Article
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