Effect of sappan wood on perforin mRNA expression in myocardium of rats after allogeneic cardiac transplantation / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 370-372, 2003.
Article
Dans Chinois
| WPRIM
| ID: wpr-304159
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of Sappan wood (SW) on the expression of perforin mRNA in myocardium of rats after allogeneic cardiac transplantation.</p><p><b>METHODS</b>The animal model of allogeneic (abdominal) cardiac transplantation was established by taking Wistar rat as provider and SD rat as receptor, perforin mRNA expression in the model's myocardium was detected by RT-PCR.</p><p><b>RESULTS</b>SW could obviously reduce the perforin mRNA expression, it also could alleviate the pathological morphology and ultrastructural damage of myocardial cells.</p><p><b>CONCLUSION</b>SW has obvious effect in antagonizing immune rejection after transplantation, the mechanism of its immunosuppression could be through lowering the perforin mRNA expression.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pharmacologie
/
Transplantation homologue
/
ARN messager
/
Médicaments issus de plantes chinoises
/
Glycoprotéines membranaires
/
Chimie
/
Transplantation cardiaque
/
Rat Wistar
/
Rat Sprague-Dawley
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Chinese Journal of Integrated Traditional and Western Medicine
Année:
2003
Type:
Article
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