Effect of yangjing zhongyu decoction on expression of insulin-like growth factor II and its receptor in endometrium of women with unexplained infertility / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 490-493, 2002.
Article
Dans Chinois
| WPRIM
| ID: wpr-304219
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of Yangjing Zhongyu Decoction (YJZYD) on expression of insulin-like growth factor II (IGF-II) and its receptor II (IGF-II R) in endometrium of women with unexplained infertility, and the relationship of which with the receptibility of endometrium to ovum implantation.</p><p><b>METHODS</b>Reverse transcription-polymerase chain reaction (RT-PCR) assay was used to detect quantitatively the expression of IGF-II and IGF-II R in 22 women with unexplained infertility before and after YJZYD treatment during mid-luteal phase.</p><p><b>RESULTS</b>The levels of IGF-II and IGF-II R before treatment were 0.794 +/- 0.453 and 0.725 +/- 0.354 (in grey level, the same below) respectively, which were significantly increased in the same phase after treatment, reaching 1.202 +/- 0.551 and 1.045 +/- 0.581 respectively (P < 0.01 and P < 0.05). Correlation analysis showed the level of IGF-II mRNA was positively correlated with the level of IGF-II mRNA either before or after treatment.</p><p><b>CONCLUSION</b>YJZYD could enhance the expression of IGF-II and IGF-II R in the endometrium during mid-luteal phase, promote the differentiation of endometrium and increase its reception to ovum implantation.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Implantation embryonnaire
/
ARN messager
/
Facteur de croissance IGF-II
/
Récepteur IGF de type 2
/
Traitement médicamenteux
/
Endomètre
/
Génétique
/
Infertilité féminine
/
Phase lutéale
/
Métabolisme
Limites du sujet:
Adulte
/
Femelle
/
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Integrated Traditional and Western Medicine
Année:
2002
Type:
Article
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