Cannabinoid receptor 1 controls nerve growth in ectopic cyst in a rat endometriosis model / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 827-830, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-304381
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether cannabinoid receptor 1 (CB1R) is involved in nerve growth in endometriosis-associated ectopic cyst.</p><p><b>METHODS</b>The effect of CB1R agonist and antagonist on the expression of pan-neuronal marker protein gene product (PGP) 9.5 in ectopic cyst was examined by immunofluorescence and Western blot in endometriosis model of 18 rats.</p><p><b>RESULTS</b>Immunofluorescence revealed that PGP 9.5 was expressed in the nerve fibers and was mainly distributed in the cyst hilum. Western blot revealed that the protein density of either PGP 9.5 (2 week 0.38 ± 0.05; 4 week 0.63 ± 0.03; 8 week 0.80 ± 0.07, P < 0.01) or CB1R (2 week 0.48 ± 0.04; 4 week 0.68 ± 0.01; 8 week 0.80 ± 0.03, P < 0.01) in the ectopic cyst increased with cyst size. In addition, compared to control group (0.75 ± 0.01), PGP 9.5 expression in the ectopic cyst was promoted by CB1R agonist ACPA (0.81 ± 0.01, P < 0.05), and inhibited by CB1R antagonist AM251 (0.67 ± 0.03, P < 0.01).</p><p><b>CONCLUSIONS</b>CB1R was involved in the nerve growth of ectopic cyst associated with endometriosis.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Nerfs périphériques
/
Pharmacologie
/
Physiologie
/
Pipéridines
/
Pyrazoles
/
Technique de Western
/
Kystes
/
Ubiquitin thiolesterase
/
Récepteur cannabinoïde de type CB1
/
Modèles animaux de maladie humaine
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Chinese Journal of Pathology
Année:
2014
Type:
Article
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